|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Whereas Apc(Min) mice developed mostly low-grade adenomas, 20% of the tumors that developed in Apc(Min)/Phlpp1(-/-) mice were invasive adenocarcinomas.
|
24530606 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas Apc(Min) mice developed mostly low-grade adenomas, 20% of the tumors that developed in Apc(Min)/Phlpp1(-/-) mice were invasive adenocarcinomas.
|
24530606 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate.
|
21840483 |
2011 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We here show that PHLPP1 expression was significantly downregulated or lost and correlated with metastatic potential in melanoma.
|
29391600 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that PHLPP1 played a suppression role in inflammatory response of glioma.
|
26971226 |
2016 |
|
Tuberous Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using pulldown and MS approaches, here we identified the TSC complex member, TBC1 domain family member 7 (TBC1D7), as a binding partner for PH domain and leucine-rich repeat protein phosphatase 1 (PHLPP1), a negative regulator of Akt kinase signaling.
|
30143532 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
|
29940243 |
2018 |
|
Myocardial Ischemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
|
29940243 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Together, these results suggest that miR-367-3p may function as an AR enhancer to increase Sorafenib chemotherapy efficacy via altering the MDM2/AR/FKBP5/PHLPP/(pAKT and pERK) signals to better suppress HCC metastasis.
|
27688096 |
2016 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that miR-367-3p may function as an AR enhancer to increase Sorafenib chemotherapy efficacy via altering the MDM2/AR/FKBP5/PHLPP/(pAKT and pERK) signals to better suppress HCC metastasis.
|
27688096 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis, and provide potential therapeutic targets for NSCLC treatment.
|
24945731 |
2014 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine what the consequences of PHLPP1 loss on BCR signaling are, we downregulated or re-expressed PHLPP1 in lymphoma cell lines and primary CLL B-cells, respectively.
|
20861921 |
2010 |
|
Lymphoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To determine what the consequences of PHLPP1 loss on BCR signaling are, we downregulated or re-expressed PHLPP1 in lymphoma cell lines and primary CLL B-cells, respectively.
|
20861921 |
2010 |
|
Adult Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To determine what the consequences of PHLPP1 loss on BCR signaling are, we downregulated or re-expressed PHLPP1 in lymphoma cell lines and primary CLL B-cells, respectively.
|
20861921 |
2010 |
|
Childhood Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To determine what the consequences of PHLPP1 loss on BCR signaling are, we downregulated or re-expressed PHLPP1 in lymphoma cell lines and primary CLL B-cells, respectively.
|
20861921 |
2010 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, PHLPP1 provides a proofreading step that maintains the fidelity of PKC autoinhibition and reveals a prominent loss-of-function mechanism in cancer by suppressing the steady-state levels of PKC.
|
30904392 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, PHLPP1 provides a proofreading step that maintains the fidelity of PKC autoinhibition and reveals a prominent loss-of-function mechanism in cancer by suppressing the steady-state levels of PKC.
|
30904392 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results suggest that several mechanisms affecting Akt isoforms, including deregulated production of PHLPP1, could underlie the alterations of skeletal muscle insulin signalling in type 2 diabetes.
|
18204829 |
2008 |
|
Gram-Negative Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data highlight a link between leptin signaling, the mTORC2/Phlpp1/Akt axis, and lysosomal activity in macrophages and have important therapeutic implications for modulating innate immunity to combat Gram-negative bacterial infections.
|
31350351 |
2019 |
|
Presenile dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The second group was treated with SCOP to induce dementia.
|
27631101 |
2017 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The second group was treated with SCOP to induce dementia.
|
27631101 |
2017 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation.
|
25617127 |
2015 |